Presentation

Hugot ogier1Jean-Pierre Hugot et Eric Ogier-Denis

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Intestinal inflammation

The team “intestinal inflammation” works exclusively on inflammatory bowel disease (IBD): Crohn’s Disease (CD) and ulcerative colitis (UC). The research is deliberately multidisciplinary with a multi-scale approach from the molecular level to patients. This is a translational research strongly associated with the gastroenterology units of Beaujon and Robert Debré hospitals. Projects aim to identify the genetic and environmental risk factors involved in these diseases and to define their interactions. The team developed original animal models to better understand the pathophysiology of IBD in particular the importance of abnormalities of endoplasmic reticulum (ER) stress and epigenetic factors (microRNAs, methylation, and acetylation) in UC and the innate immune response and function of the complex molecular “Nodosome” around Nod2 in CD. Finally, the team aim to develop new preventive and curative therapeutic approaches for IBD.

Selected publications
  • Hugot JP et al. Association of Nod-2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 411 : 599-603.
  •  Hugot JP et al. Crohn Disease : the cold chain hypothesis.Lancet 2003 ; 362 : 2012-15.
  • Treton X et al. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis Gastroenterology.2011 Sep;141(3):1024-35. 
  • Thachil E et al. Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn’s Disease Short title: Crinophagy in Crohn’s disease. Gastroenterology. 2012; 142 : 1097-1099.
  •  Jung C et al. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest. 2012; 122: 2239-51.
Team members
Team leaders Jean-Pierre Hugot, PUPH
  Eric Ogier-Denis, DR 
Researchers Arnaud Bonnard, PUPH
  Yoram Bouhnik, PUPH
  Frédéric Bretagnol, PUPH
  Dominique Cazals-Hatem, PH
  Anne Dumay, MCF
  Jean-Pierre Hugot, PUPH
  Eric Ogier-Denis, DR 
  Yves Panis, PUPH
  Xavier Treton, PH
Jérôme Viala, PH
PhD Students Meredith Flacs
Postdoctoral fellows Ulrich Meinzer
Alberto Romagnoni
Engeneers & technicians Julien Tourneur-Marsille, IE
Maryline Roy, AI